Treatment-Resistant Depression Program in San Diego

Comprehensive Treatment for Women with Treatment-Resistant Depression

When depression doesn’t respond to traditional treatments, it can feel overwhelming and discouraging. At Monima Wellness Center in San Diego, we understand the unique challenges women face when dealing with treatment-resistant depression (TRD). Our specialized, gender-specific approach combines innovative treatments like ketamine therapy with evidence-based psychotherapy to provide new hope for lasting recovery.

As a leading women’s mental health treatment center, we offer comprehensive outpatient programs specifically designed to address treatment-resistant depression through our intensive outpatient program (IOP) and partial hospitalization program (PHP). Through partnerships with trusted local providers, we integrate cutting-edge ketamine therapy, including Spravato® (intranasal esketamine), into personalized treatment plans that address the whole person.

A sad and stressed young woman sitting alone in the room

Coordinated Medical Care With Ketamine Therapy at Monima Wellness

Through our partnerships with trusted providers, we ensure:

  • Seamless ketamine therapy coordination with transportation assistance
  • Medical monitoring throughout your treatment journey
  • Collaborative care between our clinical team and medical partners
  • Insurance verification and coverage assistance

Ready to Start Your Journey?

Contact us today at 858-500-1542 to begin crafting your path to recovery.

Understanding Treatment-Resistant Depression

Treatment-resistant depression is a form of major depression that doesn’t respond adequately to at least two different antidepressant medications tried for an adequate duration and dosage. This condition affects approximately 30% of individuals with major depressive disorder, leaving many feeling hopeless about their recovery prospects.

Women with treatment-resistant depression may experience:

  • Persistent depressive symptoms despite trying multiple medications
  • Lack of improvement after 6-8 weeks of adequate antidepressant treatment
  • Recurring episodes of depression, even with ongoing treatment
  • Severe functional impairment affecting work, relationships, and daily activities
  • Co-occurring conditions such as anxiety, trauma, or substance use
  • Suicidal thoughts or behaviors that persist despite treatment

At Monima Wellness, our comprehensive neuropsychological testing helps identify the specific factors contributing to treatment resistance, ensuring we create the most effective personalized treatment plan for your recovery journey.

Our Innovative Approach to Treatment-Resistant Depression

Through our partnerships with trusted providers, Monima Wellness seamlessly integrates ketamine therapy in San Diego into our comprehensive treatment model. This collaboration allows us to maintain our clinical expertise in women’s mental health while providing access to innovative, proven treatments while enrolled in our outpatient programs.

One of the most promising advances in treating treatment-resistant depression is ketamine therapy. Unlike traditional antidepressants that target serotonin, ketamine works on the brain’s glutamate system, offering rapid relief for many who haven’t found success with conventional treatments.

Spravato® (Esketamine) Treatment:

  • FDA-approved intranasal treatment specifically for treatment-resistant depression
  • Administered in supervised clinical settings through our trusted partner network
  • Can provide relief within hours to days, rather than weeks
  • Enhances neuroplasticity, helping create new neural pathways for healing

Related: Does Ketamine Therapy Get You High?

Our treatment-resistant depression program incorporates proven therapeutic modalities:

Cognitive Behavioral Therapy (CBT)

  • Identifies and challenges negative thought patterns that perpetuate depression
  • Develops practical coping strategies for managing depressive episodes
  • Proven effective for treatment-resistant cases when combined with other interventions

Dialectical Behavior Therapy (DBT)

  • Provides skills for emotional regulation and distress tolerance
  • Particularly beneficial for women with co-occurring mood instability
  • Enhances the effectiveness of ketamine therapy through improved emotional management

EMDR Therapy

  • Addresses underlying trauma that may contribute to treatment resistance
  • Processes traumatic memories that traditional talk therapy may not reach
  • Complements ketamine therapy’s neuroplasticity effects

Cognitive Processing Therapy (CPT)

  • Specifically designed for trauma-related depression
  • Helps reframe beliefs about oneself and the world that maintain depression
  • Integrated with ketamine therapy for enhanced trauma processing

Our interdisciplinary approach recognizes that treating treatment-resistant depression requires addressing mind, body, and spirit:

Body-Based Approaches:

Mindfulness and Spiritual Practices:

  • Sound healing for emotional release and nervous system calming
  • Reiki for energy balance and deep relaxation
  • Equine therapy for mind-body-spirit holistic healing
  • Mindfulness practices to develop present-moment awareness

Levels of Care

Intensive Outpatient Program (IOP)

The Intensive Outpatient Program (IOP) at Monima is individualized for women and offers part-time, intentional, and comprehensive treatment for challenges related to mental health and trauma recovery.

IOP is designed specifically for women ready for level of support above traditional once-per-week therapy, or as a stepping stone between a full-time recovery program — such as PHP or residential treatment — and returning to their daily routines full-time.

Partial Hospitalization Program (PHP)

The Partial Hospitalization Program (PHP) at Monima provides treatment for women seeking a comprehensive and full-time mental health treatment program that fosters lasting mental, physical, and spiritual wellness.

PHP is the highest level of care available at Monima, intentionally designed for women that are ready for a step above basic therapy, psychiatric support, or IOP. Most clients take a leave of absence from work, school, or their daily routines to fully immerse themselves in healing.

Outpatient
Program (OP)

Monima Wellness offers an outpatient program (OP) to provide continued mental health support while integrating into their daily lives. This program is ideal for those transitioning from more intensive levels of care, such as PHP or intensive outpatient treatment. Sometimes referred to as aftercare, the OP emphasizes maintaining and building upon the progress achieved in previous phases, allowing clients to begin balancing their recovery with work, education, or family responsibilities. 

Begin Your Healing Journey

Don’t let treatment-resistant depression define your future. At Monima Wellness Center, we believe that every woman deserves access to innovative, compassionate care that addresses her unique needs. Our specialized approach combines the latest advances in ketamine therapy with proven psychotherapy and holistic healing modalities in a supportive, women-centered environment.

Recovery from treatment-resistant depression is possible. Let our expert team guide you toward the breakthrough you’ve been seeking.

Call us today or request that we contact you to begin your journey toward lasting healing.

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FAQs

If you’ve tried at least two different antidepressants for adequate time periods without significant improvement, you may have treatment-resistant depression. Our comprehensive assessment can help determine this.

When administered in supervised clinical settings like those coordinated through our trusted partners, ketamine therapy has a strong safety profile and is FDA-approved for treatment-resistant depression.

Many clients experience improvement within days to weeks of beginning our integrated treatment approach, though individual timelines vary.

Many insurance plans cover Spravato® for treatment-resistant depression. Our team will help verify your specific coverage.